Research progress on the relationship between TET1 and tumor invasion and metastasis / 国际外科学杂志
International Journal of Surgery
;
(12): 65-68, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-693199
ABSTRACT
TET1 has been discovered capable of promoting DNA demethylation by mediating 5-methylcytosine to inhibit the genesis and development of cancer.Epithelial-Mesenchymal transition is a complex cellular program in cancer progression and metastasis,whose hallmark is loss of cell polarity and cell adhesion and acquirement of migration and invasion abilities,leading tumor cells into blood vessel and lymphatic vessels to form new metastatic lesions.Epigenetics plays a vital role in epithelial-mesenchymal transition.This review focuses on the relationship of TET1,epigenetics and epithelial-mesenchymall transition,and the research progression of TET1's role in cancer invasion and metastasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Surgery
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS