Role of wild-type p53-induced phosphatase 1 in cancer / 国际外科学杂志

ABSTRACT

Wild-type p53-induced phosphatase 1 is a member of the protein phosphatase family and is an established oncogene due to its dephosphorylation of key protein in pathways and negative control of the DNA damage response system.Wild-type p53-induced phosphatase 1 serves a major role in tumorigenesis,progression,invasion,distant metastasis and chemotherapy resistance in various types of human cancer.Therefore,it may be a potential biomarker and therapeutic target in the diagnosis and treatment of cancer.In the paper,the current knowledge on the role of wild-type p53-induced phosphatase 1 in cancer is discussed.