Relationship between insulin resistance related factors and colon cancer stem cells / 国际肿瘤学杂志

ABSTRACT

Colon cancer stem cells have uncontrolled self-renewal capabilities,a potential of forming colon cancer and resistance to conventional anti-tumor therapy.Insulin resistance related factors mainly include adiponectin,leptin and various inflammatory factors.Various insulin resistance related factors have different effects on the proliferation,apoptosis,migration,carcinogenesis of colon cancer stem cells through different mechanisms.Understanding the relationship between various insulin resistance related factors and colon cancer stem cells can provide a new treatment for colon cancer.