Interferon alpha-inducible protein 27 and tumor / 国际肿瘤学杂志

ABSTRACT

Interferon alpha-inducible protein 27 (IFI27) is a newly discovered protein that participates in biological functions such as apoptosis,cell autophagy,oncolytic and immunoregulation.It also plays a major role in promoting tumor development,such as in breast cancer,ovarian cancer,liver cancer,squamous cell carcinoma and so on.Besides,studies have shown that IFI27 can interact with signal transducer and activator of transcription 1,microRNAs,interferon regulatory factor 4 and other genes,which promotes the development of tumors.Therefore,IFI27 is expected to be a marker for the occurrence and development of tumors,providing a new target for cancer therapy.