Expression and significance of tripartite motif family proteins in hepatocellular carcinoma / 国际肿瘤学杂志

ABSTRACT

Tripartite motif (TRIM) family,a very important protein family,has various functions in cellular biological processes including intracellular signal transduction,cell growth and apoptosis,innate immunity,autophagy and tumorigenesis.The specific expressions of TRIM in hepatocellular carcinoma are proved by many researches,which are closely related to the occurrence,metastasis and prognosis of hepatocellular carcinoma.TRIM are expected to be markers for the occurrence and development of hepatocellular carcinoma,and have broad prospects in the early diagnosis,therapy and prognosis of hepatocellular carcinoma.