Progress in synaptic mechanism in epileptogenesis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 90-94, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-693781
ABSTRACT
Recurrent seizures lead to abnormal expression of synaptic proteins,reorganization of synapse and formation of abnormal neuron network.Recently,it is identified that the synaptic proteins are involved in epileptogenesis.The abnormal expression of several synaptic regulatory proteins and postsynaptic membrane receptor proteins may result in epilepsy.The ion channels usually are the action target of most antiepileptic drugs.However,carbamazepine and zonisamide may interact with syntaxin and/or soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex to exert its function of anti-epilepsy.The synaptic vesicle protein 2A is the action target for new anti-epileptic drugs,including levetiracetam,brivaracetam and seletracetam.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2018
Tipo del documento:
Artículo
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