Progress in the study on bone morphogenetic protein 2/4 in central nervous system / 中南大学学报(医学版)

ABSTRACT

As a member of transforming growth factor β (TGF-β) family,bone morphogenetic proteins (BMPs) are multi-functional factors and play critical roles in heart,cartilage,neural development and postnatal bone formation.It has been demonstrated that among the family,BMP2/4 have been reported to be especially important for the developmental and maturation of central nervous system (CNS).It has different,even opposite functions,in certain given circumstances,which could be a potential risk for BMPs' clinical use.