YAP/TAZ regulates multiple signal pathways in the genesis and development of hepatic fibrosis / 中南大学学报(医学版)

ABSTRACT

Hepatic fibrosis is a repair response to liver injury,and hepatic stellate cell activation is the center of hepatic fibrosis,which involves Hippo,Notch,Wnt/β-catenin,and TGF-β/Smad signaling pathways.YAP/TAZ is an important nucleus factor for Hippo tumor suppressor pathway and its activity is the key to the growth of whole organs,cell proliferation,and specific amplification of progenitor cells in the process of tissue renewal and regeneration.As the hub of signaling pathways,such as Hippo,Notch,Wnt/β-catenin,TGF-β/Smad signaling,YAP/TAZ regulates the genesis and development of liver fibrosis.