Research progress in treatment of cisplatin resulted in premature ovarian failure / 基础医学与临床

ABSTRACT

Cisplatin,as a first-line clinical cancer chemotherapy drug,because of its poor treatment options,when kill-ing the target cells it can have cytotoxicity effects on the normal tissue and cells,leading the women cancer patients of gestational age to ovarian dysfunction involved,causing adverse reactions such as premature ovarian failur and infertil-ity. Cisplatin can activate ovarian cell apoptosis,oxidative stress response and multiple signaling pathways through the interaction of more factors to induce ovarian damage. How to effectively prevent or eliminate the damage of ovarian failure caused by chemotherapy drugs has caused extensive concern and research in the medical field.