The Function of 5-HT(1A) Receptor and Pharmacotherapy / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 253-262, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-69460
ABSTRACT
5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A) autoreceptor desensitization plays an important role in the treatment of depression and anxiety. 5-HT(1A) receptor stimulation may also mediate the neurogenesis of prefrontal cortex and hippocampus. The 5-HT(1A) agonism has an important meaning in the treatment of schizophrenia. Most atyptical antipsychotics have the property of 5-HT(2A) antagonist, and some have that of 5-HT(1A) agonist. In the various regions of brain, 5-HT(1A) and 5-HT(2A) have the functionally antagonistic properties. Recently, 5-HT(1A) receptor-related agents have been investigated in the treatment of acute ischemic stroke and Alzheimer's disease. Therefore, the further understanding about the 5-HT(1A) receptors in the brain functions will provide the development of future drugs and the advancement of psychopharmacology.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ansiedad
/
Psicofarmacología
/
Esquizofrenia
/
Antipsicóticos
/
Encéfalo
/
Serotonina
/
Felodipino
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Corteza Prefrontal
/
Autorreceptores
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Año:
2006
Tipo del documento:
Artículo
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