Research advances in the role of CCL20/CCR6 in liver cancer and other tumors / 临床肝胆病杂志

ABSTRACT

The role of chemokines/receptors in the pathophysiological activities such as inflammation and tissue injury has been clarified .In recent years, there have been increasing studies on their effect on tumors in the tumor microenvironment .This article reviews research advances in C -C motif chemokine ligand 20 (CCL20) and its receptor CCR6 in liver cancer and other tumors in recent years and analyzes the possible mechanism by which CCL20 and CCR6 promote tumor progression and their effect on tumor prognosis .Blocking CCL20/CCR6 interaction may provide a new direction for the targeted therapy for liver cancer.