The ROC curve combined Logistic regression analysis evaluate the diagnostic value of plasma miR-31-5p and miR-134-5p for Schizophrenia / 临床检验杂志

ABSTRACT

Objective To examination the expression levels of plasma miR-31-5p and miR-134-5p in Schizophrenia,Primary discussion for their diagnostic value.Methods Collecting Schizophrenia group,BDAP group and healthy control group,with 90 cases in each group.Detection of plasma miR-31-5p and miR-134-5p expression levels by real-time fluorescent quantitative PCR,the statistical analysis were used to verify differentially expressed miRNA.The diagnostic value of miRNA were evaluated by made receiver operating characteristic(ROC) curves and stepwise Logistic regression analysis.Results The expressed level of miR-31-5p was significantly lower in Schizophrenia group than others (x2 =9.223,P ＜ 0.05).The different expression of miR-3 1-5p compared Schizophrenia group with control group had statistical significance(q =7.85,P ＜ 0.05).The expressed level of miR-31-5p was significantly lower in Schizophrenia group than others(x2 =29.111,P ＜0.05).The different expression of miR-134-5p had statistical significance compared Schizophrenia group with control group(x2 =20.40,P ＜ 0.05),compared Schizophrenia group with BPAD group (x2 =23.18,P ＜ 0.05).The AUCROC of miR-31-5p was 0.617,senstivity was 73.3％,and specificity was 54.4％.The AUCROC of miR-134-5p was 0.696,senstiivity was 84.4％,and specificity was 48.9％,The combined forecast variables of PRE's AUCROC was 0.695,sensitivity was 84.4％,specificity was 48.9％.Conclusion Signal miR-134-5p and it combine with miR-31-5p had the same diagnostic value in SZ,both of them had better diagnostic value than signal miR-31-5p.