Associations of IL-6-174G ＞ C and-634C ＞ G polymorphisms with type 2 diabetic nephropathy: a meta-analysis / 临床检验杂志

ABSTRACT

Objective To perform a meta-analysis on the associations of interleukin (IL)-6-174G ＞ C (rs1800795) and-634C ＞ G (rs1800796) polymorphisms with type 2 diabetic nephropathy (DN).Methods The data on the studies about the associations of IL-6-174G ＞ C and-634C ＞ G polymorphisms with type 2 DN were collected from Pubmed,Embace,CNKI,Wan Fang and VIP database during their inception and April 2017.The statistical analysis was performed with STATA 14.0 and Review manager 5.3 softwares.The heterogeneity in the eligible studies was assessed by Q-statistic and I2 statistic.When the significant heterogeneity was found,the random effect model was used for meta-analysis,otherwise,the fixed effect model was used.The publication bias was evaluated with funnel and Begger graphs.The pooled odds ratios (OR) and corresponding 95％ confidence intervals (95％ CI) were calculated for evaluating the associations of IL-6-174G ＞ C and-634C ＞ G polymorphisms with type 2 DN.In addition,the sub-group analysis was performed according to the regions of subjects.Results A total of 11 studies were enrolled,The studies on the association of IL-6-174G ＞ C polymorphism with type 2 DN included 1 688 subjects,while those on the association of IL-6-634C ＞ G with type 2 DN included 2 180 subjects.In the association analysis of IL-6-174G ＞ C polymorphism with type 2 DN of Asian population,the significant relationship was detected in an allelic genetic model (OR =0.461,95％ CI0.274-0.777,P ＜ 0.01),a homozygote model (OR =0.126,95％ CI0.022-0.734,P =0.021),a recessive genetic model (OR =0.146,95％ CI0.026-0.827,P =0.030) and a dominant genetic model (OR =0.504,95 ％ CI0.273-0.930,P =0.028),but not in a heterozygote model (OR =0.606,95 ％ CI0.321-1.143,P =0.122).There was no significant relationship between IL-6-174G ＞ C polymorphism and type 2 DN in European population.In the association analysis of IL-6-634C ＞ G polymorphism with type 2 DN of Asian population,the significant relationship was found in an allelic genetic model (OR =1.467,95％ CI1.238-1.737,P ＜0.01),a homozygote model (OR =2.793,95％ CI1.844-4.230,P =0.021),a recessive genetic model (OR =2.296,95 ％ CI1.586-3.323,P ＜ 0.01) and a dominant genetic model (OR =1.377,95％CI1.109-1.711,P ＜ 0.01),but not in a heterozygote model (OR =1.733,95％ CI0.932-1.476,P =0.174).There was no significant relationship between IL-6-634C ＞ G polymorphism and type 2 DN in European population.Conclusion In Asian population,IL-6-174CC genotype may prevent the progression of type 2 DN,however,IL-6-634GG genotype may promote the development of type 2 DN.But in European population,there is no relationship between IL-6-174G ＞ C and-634C ＞ G polymorphisms and type 2 DN.