Effect of dexmedetomidine on liver and kidney function in patients undergoing spinal surgery / 临床麻醉学杂志

ABSTRACT

Objective To observe the effect of dexmedetomidine on liver and kidney function in patients undergoing spinal surgery.Methods Sixty patients (31 males and 29 females,aged 49-78 years)of BMI 19-30 kg/m2and ASA physical status Ⅰ-Ⅲ who underwent surgery for posterior lum-bar interbodyfusion under general anesthesia from December 2016 to May 2017 in our hospital were selected as the research object.Patients were randomly divided into dexmedetomidine group (group D)and control group (group C)(n=30 each).In group D,DEX was infused over 10 min with the loading dose 0.5-1.0 μg/kg and followed by 0.2-0.5 μg·kg-1·h-1as a maintenance dose.Group C received the same volume of saline.The blood samples were obtained from the patient at 30 min be-fore anesthesia induction (T0),the end of the operation (T1)and 2 days after operation (T2)for re-cording monitoring index and determination of the levels of plasma CysC,Cr,UREA,ALT and AST.The dosages of remifentanil and propofol,hospital stay and the adverse reactions after the sur-gery (such as postoperative hypotension or cardio-cerebral vascular events)were compared between the two groups.Results Compared with T0,the levels of ALT,AST,Cr and UREA in the two groups were significantly reduced at T1(P<0.05),the levels of ALT,UREA of two groups and the levels of AST of group D were significantly reduced at T2(P<0.05).The levels of ALT,AST,U-REA at T1,T2and the levels of Cr at T1in group D were significantly lower than group C (P<0.05).Compared with group C,the urine volume of group D increased significantly (P<0.05),and there was a significant decrease in the dosage of remifentanil and propofol in group D (P<0.05). There was no significant difference in the incidence of adverse reactions and hospitalization time be-tween the two groups.Conclusion Spinal surgery patients during general anesthesia using dexme-detomidine,significantly reduce the amount of intraoperative anesthetic,protect liver and kidney function and increase the safety during anesthesia.