Effect of early intensive blood pressure reduction on outcome in patients with cerebral hemorrhage, a Meta-analysis / 临床神经病学杂志

ABSTRACT

Objective To determine the effect of early intensive blood pressure reduction on outcome in patients with cerebral hemorrhage.Methods Pubmed,Embase and Web of Science databases were searched to identify relevant randomized controlled trials(RCT)published before Sep 1st 2017.Meta analyzed the effect of early intensive blood pressure control and standard blood pressure control on outcome of patients with cerebral haemorrhage.Results Six RCTs include 4376 patients were included in analysis.The mortality in intensive and standard were 10.8%(235/2177)and 10.8%(238/2199), respectively; while the incidence of major disability was 38.1%(801/2103)and 39.9%(848/2123), respectively.Compare with standard blood pressure control, intensive blood pressure reduction did not reduce the mortality(RR=1.00,95%CI0.84 -1.18,P=0.98;I2=0%)and the major disability incidence(RR=0.95,95%CI0.88 -1.03,P=0.23;I2=0%)in patients with cerebral hemorrhage.Conclusion Early intensive blood pressure reduction can not significantly improve the outcome of cerebral hemorrhage patients.