Clinical and EEG analysis of 12 cases of anti-N-methyl-D-aspartic acid receptor encephalitis / 临床神经病学杂志

ABSTRACT

Objective To explore the dynamic changes of EEG and the clinical characteristics of anti -N-methyl-D-aspartic acid(NMDA)receptor encephalitis.Method The clinical data of 12 patients with anti-NMDA receptor encephalitis were analyzed retrospectively.Results The study included 12 cases of diagnosed patients,6 males and 6 females,aging from 14 to 43 years old,with hospital stay 13 -84 d.The clinical features suggested mental and behavior disorder in 12 cases,involuntary movement in 12 cases,coma in 6 cases,seizure in 11 cases(include status epilepticus in 4 cases),assisted respiration and stayed in neurology intensive care unit in 6 cases,lung infection in 8 cases.The EEG on admission showed height abnormal in 7 cases,moderately abnormal in 4 cases,mild abnormal in 1 case,δ brush in 7 cases,generalized slow waves in 11 cases,asymmetric in 4 cases and epileptic discharge in 6 cases.The EEG at discharge showed height abnormal in 3 cases,moderately abnormal in 7 cases,mild abnormal in 1 case,δ brush in 4 cases, generalized slow waves in 7 cases, asymmetric in 4 cases and epileptic discharge in 1 cases.Conclusion The EEG plays an important role in the diagnosis of anti-NMDA receptor encephalitis,and the δ brush may be is a special display.