Expression of E-cadherin and β-catenin in thymomas and their significance / 临床与实验病理学杂志

ABSTRACT

Purpose To discuss the expression of E-cadherin and β-catenin proteins and genes in non-invasive and invasive group of thymoma.Methods The 120 paraffin embedded thymoma tissues from Dongguan People's Hospital from 2012 to 2016 were being divided into non-invasive group and invasive group based on performance under the microscope,Masaoka clinical staging methods and clinical imaging data.These cases were also being used for immunohistochemical (IHC) tests and gene fluorescence in situ hybridization(FISH) of E-cadherin and β-catenin.Results 55 cases were included in invasive group and 65 cases in non-invasive group.Antibodies and IHC tests were used to examine the expression of E-cadherin and β-catenin in 120 cases of thymoma.The expression difference of E-cadherin and β-catenin protein in non-invasive and invasive thymoma had statistical significance (P ＜ 0.05).In non-invasive and invasive thymoma cases,difference among groups of E-cadherin regrading gene expression deletion had statistical significance (P＜ 0.05).Difference among groups in β-catenin expression also had statistical significance (P ＜ 0.05).Conclusion IHC tests of E-cadherin and β-catenin protein and FISH tests of E-cadherin and β-catenin gene indicate that there are significances in differential diagnosis between the non-invasive and invasive thymomas.