Improvement of visual acuity and VEP after optic nerve contusion by NGF and its safety analysis / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM:To investigate the effect of neuropathic factor ( NGF) on visual acuity and visual evoked potential ( VEP) in patients with optic nerve contusion.?METHODS:Totally 78 patients ( 78 eyes ) with optic nerve contusion were selected. From January 2013 to June 2016, 39 cases ( 39 eyes ) were divided into observation group and control group respectively according to the random number table method. Prednisone, vitamins and mecobalamin tablets treatment were given to both groups, based on that, the observation group was given NGF treatment, continuous treatment of 2 courses (21d for a course of treatment).?RESULTS: There was no significant difference in visual field defect and visual field sensitivity between the observation group and the control group before treatment (P>0.05). After treatment, the visual field defect degree of the observation group was smaller, the visual field sensitivity was better than that of the control group ( P<0. 05). There was no significant difference in P100 wave latency and P100 wave amplitude between the observation group and the control group before treatment (P>0. 05). After treatment, the P100 wave latency of the observation group was significantly shorter than that of the control group ( P<0. 05 ). The amplitude of P100 wave in the observation group was higher than that in the control group (P<0. 05). After treatment, the visual acuity and visual field sensitivity of the observation group was significantly better than that of the control group (P<0. 05).?CONCLUSION:NGF treatment for optic nerve contusioncan significantly improve the patient's visual acuity, VEP indicators, reduce visual field defects, improve visual field sensitivity.