Research progress of radiofrequency ablation treatment of locally advanced pancreatic cancer / 复旦学报（医学版）

ABSTRACT

The pancreatic cancer is one of the most common digestive neoplasm with difficult early diagnosis and poor prognosis,which is considered as the most malignant tumor.In reality,patients always have no obvious clinical symptoms before diagnosis,and they often lose the chance of operation because of distant metastases at diagnosis.Currently,gemcitabine-based chemotherapy has became the first choice to patients with locally advanced pancreatic cancer.Nowadays,radiofrequency ablation as a new treatment,is mainly for patients in locally advanced pancreatic cancer with non-metastatic,unresectable lesions,or insensitive to chemotherapy.Due to its minimal invasion and accuration,a large number of preclinical experiments and clinical studies have confirmed that radiofrequency ablation shows its safety and efficacy to locally advanced pancreatic cancer,which becomes more and more popular.This paper aims to discuss the current situation and advancement in radiofrequency ablation treatment of locally advanced pancreatic cancer.