Progression of studies on virulence factors and pathogenesis of Bordetella pertussis / 中华实用儿科临床杂志

ABSTRACT

In 1906,it was confirmed that the pertussis was caused by Bordetella pertussis (BP).Virulence factors of BP had been studied widely for over a hundred years,however,the pertussis pathology remains largely unknown.The development of a baboon model will promote the study of the pathogenesis of BP infection and disease,and the understanding about the pathogenesis is helpful for the prevention and therapeutics of pertussis.