Improving the understanding of pediatric myelodysplastic syndrome / 中华实用儿科临床杂志

ABSTRACT

Myelodysplastic syndromes(MDS)represent a heterogeneous group of myeloid neoplasms initiated from stem cells and/or progenitor cells,which is primarily a disease of elderly.In childhood,MDS is uncommon.As for its mechanism,there has been a considerable improvement,involving cytogenetics,molecular biology.Besides,the rela-tionship between hematological clonal evolution and initiation,development and prognosis of MDS,has also been repor-ted systemically.These mechanisms are summarized and some characteristics of pediatric cases are reviewed.