Effect of anticoagulant therapy on prevention of thrombosis in PICC patients with lung cancer with hypercoagulability / 中国实用护理杂志

ABSTRACT

Objective To explorethe efficacy of anticoagulation therapy with peripherally inserted central venous catheter (PICC) for prevention of venous thrombosis in patients with lung cancer with hypercoagulability. Methods During the period from August 2015 to December 2016,30 patients in our hospital were enrolled as the observation group, and 30 patients from May 2014 to July 2015, with lung cancer treated with PICC catheter in our hospital were selected as the control group.In the control group, PICC during intubation by conventional methods to prevent the occurrence of venous thrombosis;while in the observation group with the additional treatment before and after anticoagulant therapy catheter based on routine prevention. Venous thrombosis incidence and the indwelling time of PICC were compared between two groups. Results The incidence of thrombosis in observation and control groups was 0 and 20% respectively,with significant difference between the two groups(P=0.024).The PICC retention time in observation group and control group was 95.5 (21.00, 117.25) days and 108 (97.00,130.25) days, the difference between the two groups was statistically significant (Z =-2.249, P = 0.025). Conclusions Anticoagulation treatment with PICC catheter before and after in hypercoagulability lung cancer patients can significantly improve the hypercoagulable state of patients,effectively prevent venous thrombosis,and prolong the PICC retention time.