Expression and clinical significance of plasma long non-coding RNA MALAT1 in patients with oral squamous cell carcinoma / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 188-192, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-697482
ABSTRACT
Objective:
To investigate the expression of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in plasma of patients with oral squamous cell carcinoma (OSCC) and its clinical significance.Methods:
70 OSCC patients and 50 healthy controls were included. The relative expression of MALAT1 in plasma was examined by quantitative realtime PCR. The expression of MALAT1 in plasma in 15 OSCC patients was analyzed retrospectively 30 days after operation.Results:
The expression level of MALAT1 in plasma of OSCC patients was significantly higher than that of healthy controls(P< 0. 001). The expression level of MALAT1 in OSCC patients was significantly correlated with TNM stage, tumor differentiation and lymph node metastasis(P< 0. 05). After operation the expression level of MALAT1 in plasma of OSCC patients was significantly decreased(P< 0. 001). The AUC of the diagnosis of OSCC with MALAT1 was 0. 814, and the sensitivity and specificity were 87. 43% and 72. 00% respectively.Conclusion:
MALAT1 can be used as an auxiliary diagnostic marker for OSCC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Practical Stomatology
Año:
2018
Tipo del documento:
Artículo
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