Correlation of bone mineral density with skeletal muscle content and physical activity / 中国组织工程研究

ABSTRACT

BACKGROUND: Bone mineral density is the most important indicator for bone level. Osteoporosis is a worldwide problem, and there is no safe and effective radical treatment. It can only be prevented, so bone mineral density arise more attention. OBJECTIVE: To explore the relationship between skeletal muscle content, physical activity level and bone mineral density in older adults, so as to provide theoretical basis for preventing osteoporosis treatment. METHODS: Totally 111 subjects aged 40 to 84 years were recruited randomly. The bone mineral density was measured by double energy X-Ray bone density meter, and the human skeletal muscle content, fat content and percentage of skeletal muscle were measured by human body component analyzer. The variance analysis was used for multiple group comparisons in different age groups, LSD method for comparisons between groups, and Pearson correlation analysis for correlation analysis. RESULTS AND CONCLUSION: Bone mineral density was significantly related to the physical activity, body mass, and skeletal muscle content (r=0.30, 0.41, and 0.45, P ＜ 0.01). For middle and older adults, skeletal muscle content, physical activity level and body mass were positively related to bone mineral density. Age and bone mineral density had a negative relationship. These results indicate that physical activity is an important factor affecting bone density, and higher level of physical activity is beneficial to maintain and improve bone mineral density. Increasing muscle mass and improving body composition can improve bone mineral density.