Clinical analysis of Listeria sepsis in newborns / 中国小儿急救医学

ABSTRACT

Objective To explore the clinical features and discuss the diagnosis and treatment of neonatal sepsis caused by Lesteria. Methods We collected 22 newborn cases of Listeriosis admitted in neonatal intensive care unit from January 2014 to March 2018. The diagnosis of Listerosis was confirmed by blood culture. The clinical features, assistant examination results, drug sensitivity test and therapeutic effect were analyzed. The prognosis of Listeria sepsis was traced. Results Clinical features included dyspnea (15 cases),fever (3 cases),convulsion(3 cases). Ten cases complicated purulent meningitis,3 cases com-plicated pneumonia and 2 cases complicated shock,1 case complicated with neonatal necrotizing enterocolitis. Laboratory findings showed that white blood cell count ( >25 × 109/L) increased in 7 cases,decreased ( <5 × 109/L) in 5 cases,and C-reactive protein elevated in 21 cases. Head MRI showed intracranial hemorrhage (6 cases),neonatal white matter injury (5 cases) and hydrocephalus (1 case). Drug sensitivity test showed that Lesteria were sensitive to sulfamethoxazole, penicillin and ampicillin. Ten cases were cured, 6 cases improved,and 6 cases died. Conclusion Neonatal Listeria sepsis is a serious infectious disease. It is very important to recognize its early symptoms. Early detection of pathogens and targeted treatment can help improve prognosis and reduce mortality.