Therapeutic effect of Shenfu injection combined recombinant human brain natriuretic peptide on acute left heart failure / 心血管康复医学杂志

ABSTRACT

Objective:To explore therapeutic effect of Shenfu injection combined recombinant human brain natriuret-ic peptide(rhBNP)on patients with acute left heart failure(ALHF).Methods:A total of 92 ALHF patients treated in our hospital were selected.They were divided into rhBNP group(n=46)and combined treatment group(n=46, received Shenfu injection combined rhBNP),both groups were treated for two weeks.Cardiac function,kidney function and blood gas analysis indexes before and after treatment,and therapeutic effect after treatment were re-corded and compared between two groups.Results:Compared with before treatment,there were significant im-provements in cardiac function,kidney function and blood gas indexes in both groups after treatment,P<0.01 all. Compared with rhBNP group,there were significant rise in left ventricular ejection fraction[(51.21 ± 4.23)% vs. (56.02 ± 5.02)%],left ventricular fractional shortening[(28.02 ± 4.78)% vs.(32.78 ± 4.02)%]and partial pres-sure of oxygen in artery[(62.45 ± 6.02)mmHg vs.(75.56 ± 5.78)mmHg],and significant reductions in left ven-tricular end-diastolic dimension[(49.56 ± 5.02)mm vs.(45.12 ± 6.02)mm],arterial partial pressure of carbon dioxide[(41.78 ± 5.89)mmHg vs.(35.78 ± 6.02)mmHg],serum creatinine[(92.02 ± 5.78)μmol/L vs.(86.45 ± 8.12)μmol/L]and blood urea nitrogen[(5.99 ± 1.12)mmol/L vs.(4.56 ± 1.02)mmol/L]in combined treat-ment group,P<0.01 all.After treatment,total effective rate of combined treatment group was significantly higher than that of rhBNP group(95.56% vs.76.08%,P<0.007).Conclusion:Shenfu injection combined rhBNP treat-ment can significantly improve cardiac function,kidney function and blood gas indexes with significant therapeutic effect in ALHF patients,which is worth extending.