Application of intravenous pump infusion of large dose amiodarone in paroxysmal atrial fibrillation / 心血管康复医学杂志

ABSTRACT

Objective:To study therapeutic effect of intravenous pump infusion of large dose amiodarone on paroxys-mal atrial fibrillation(PAF).Methods:A total of 128 PAF patients,who were treated in our hospital from Jan 2014 to Dec 2016,were selected.The patients were randomly and equally divided into propafenone group and amioda-rone group,both groups received corresponding therapy based on anticoagulant and basic treatment for six months. Fibrinogen(Fg),hematocrit(HCT),plasma viscosity(np),erythrocyte sedimentation rate(ESR),whole blood high shear viscosity(nbh)and whole blood low shear viscosity(nbl),QTc interval,PR interval and QRs wave dura-tion,levels of hsCRP,TNF-α and IL-6 before and six months after treatment were observed and compared between two groups.Results:Compared with before treatment,after six-month treatment,there were significant reductions in Fg,HCT,np,ESR,nbh,nbl,levels of hsCRP,TNF-α and IL-6,and significant rise in QTc interval in two groups,P=0.001 all.Compared with propafenone group after six-month treatment,there were significant reduc-tions in Fg[(357.48 ± 35.82)g/L vs.(318.83 ± 32.58)g/L],HCT[(44.68 ± 4.75)% vs.(32.44 ± 3.38)%],np [(1.74 ± 0.18)mPa·s vs.(1.15 ± 0.12)mPa·s],ESR[(18.82 ± 1.93)mm/h vs.(14.83 ± 1.52)mm/h],nbh [(5.22 ± 0.54)mPa·s vs.(4.05 ± 0.42)mPa·s],nbl[(8.68 ± 0.86)mPa·s vs.(7.18 ± 0.73)mPa·s],levels of hsCRP[(5.76 ± 0.59)μg/ml vs.(5.22 ± 0.54)μg/ml],TNF-α[(88.76 ± 10.43)ng/L vs.(55.16 ± 6.82)ng/L]and IL-6[(92.52 ± 10.44)ng/L vs.(60.75 ± 7.38)ng/L],and significant rise in QRc interval[(0.40 ± 0.05) s vs.(0.45 ± 0.07)s]in amiodarone group,P=0.001 all.Total effective rate of amiodarone group was significant-ly higher than that of propafenone group(90.63% vs.75.00%),P=0.019. There was no significant difference in total incidence rate of adverse reactions between two groups,P=0.818. Conclusion:Intravenous pump infusion of large dose amiodarone can significantly improve hemodynamics and QTc interval,reduce serum levels of inflamma-tory factors with significant therapeutic effect and reliable safety in PAF patients,which is worth extending.