Efficacy of sequential administration of artesunate and artesunate-amodiaquine for the treatment of falciparum malaria in South Sudan / 新乡医学院学报

ABSTRACT

Objective To investigate the efficacy of sequential administration of artesunate injection and artesunateamodiaquine tablets for the treatment of falciparum malaria in South Sudan.Methods The clinical data of thirty-one patients with falciparum malaria in Level One Hospital of the Chinese Peacekeeping Infantry Battalion from April 2016 to July 2017 were analyzed retrospectively.All patients were administered artesunate injection (120 mg for the first time,60 mg 4 h later,then 60 mg once daily) by intramscular injection for 1-3 d.The patients took orally artesunate-amodiaquine tablets (2 tablets) at 24,48,72 h after the body temperature restored to normal (totally 6 tablets).The efficacy of this sequential treatment for falciparum malaria was observed.Results The total cure rate of the 31 falciparum malaria patients was 100.0％ (31/31);the cure rate of patients after 3 days treatment was 90.3％ (28/31) and the cure rate of patients after 3-6 days treatment was 9.7％ (3/31).Mild side effects,such as nausea,vomiting,anorexia,abdominal distension,diarrhea or dizziness were observed in 4 patients (12.9％) and all these symptoms disappeared after the end of treatment.Conclusion The sequential administration of artesunate injection and artesunate-amodiaquine tablets has optimal curative efficacy on falciparum malaria in South Sudan,and the tolerance is well.