Influencing factors for venous patency rate in patients with deep venous thrombosis of lower limbs treated with inferior vena cava filter combined with catheter-directed thrombolysis / 新乡医学院学报

ABSTRACT

Objective To investigate the influencing factors for venous patency rate in patients with deep venous thrombosis(DVT) of lower limbs treated with inferior vena cava filter(IVCF) combined with catheter-directed thrombolysis.Methods A total of 120 patients with DVT of lower limbs who underwent IVCF combined with catheter-directed thrombolysis were selected from March 2014 to March 2017 in Zhumadian Central Hospital.The patients were divided into poor effect group (patency rate ＜ 50％) and good effect group (patency rate ≥ 50％) according to venous patency rate after treatment.The clinical data were compared between the two groups.The influencing factors for venous patency rate in patients with DVT of lower limbs after IVCF placement and catheter-directed thrombolysis were analyzed by logistic regression.Results Among the 120 pauems with DVT of lower limbs,the venous patency rate was less than 50％ in 62 cases (poor effect group),and the venous patency rate was equal to or greater than 50％ in 58 cases (good effect group).The proportion of patients with high blood pressure,diabetes mellitus and malignant tumor in good effect group was significantly lower than that in poor effect group (P ＜0.05);there was a significant difference in DVT staging and location between the two groups (P ＜ 0.05);the levels of platelet count,white blood cell count and plasma fibrinogen in good effect group were significantly lower than those in poor effect group (P ＜ 0.05).There was no significant difference in sex,age,operation history,trauma history and D-dimer level between the two groups (P ＞ 0.05).Multivariate logistic regression analysis showed that white blood cell count,plasma fibrinogen,DVT staging and location were the influencing factors for venous patency rate after IVCF placement and catheter-directed thrombolysis in patients with DVT of lower limbs (P ＜ 0.05);but hypertension,diabetes mellitus,malignant tumor and platelet count were not related to the venous patency rate (P ＞ 0.05).Conclusion White blood cell count,plasma fibrinogen,DVT staging and location are the influencing factors for venous patency rate after IVCF placement and catheter-directed thrombolysis in patients with DVT of lower limbs.Relevant measures should be formulated in order to improve the treatment effectiveness.