Effect of butylphthalide on the neurological function and the levels of serum S100B,homocysteine, angiopoietin-1 in patients with acute cerebral infarction / 新乡医学院学报

ABSTRACT

Objective To investigate the effect of butylphthalide on the neurological function and the levels of (S-100B),homocysteine(Hcy),angiopoietin-1(ANG-1)in patients with acute cerebral infarction(ACI). Methods A total of 84 patients with ACI were selected from January 2016 to September 2017 in Henan Rongjun Hospital. The patients were divided into observation group and control group according to the treatment method,with 42 cases in each group. The patients in the two groups were treated with antithrombosis,blood sugar and blood pressure control,nutritional support,infection prevention and other conventional treatment measures. On the basis of routine treatment,the patients in the observation group were treated with butylphthalide injection 100 mL by intravenously guttae,twice a day for two weeks. The neurologic impairment of the patients in the two groups was assessed by the National Institutes of Health Stroke Scale(NIHSS)before and after treatment. The mental state and cognitive function of the patients in the two groups were scored by the mini-mental state examination(MMSE). The levels of serum S100B and ANG-1 were detected by Enzyme-linked immunosorbent assay. The level of Hcy was detected by AU480 automatic biochemical analyzer. The curative effect was evaluated after two weeks of treatment,and the adverse reac-tions of the patients were observed. Results There was no significant difference in the scores of NIHSS and MMSE between the two groups before treatment(P > 0. 05). The NIHSS score after treatment was significantly lower than that before treatment, and the MMSE score was significantly higher than that before treatment in the two groups(P < 0. 05). The NIHSS score in the observation group was significantly lower than that in the control group,and the MMSE score was significantly higher than that in the control group after treatment(P < 0. 05). There was no significant difference in serum S100B,Hcy and ANG-1 levels be-tween the two groups before treatment(P > 0. 05). The levels of serum S100B and Hcy after treatment were significantly lower than those before treatment,and the ANG-1 level was significantly higher than that before treatment in the tao groups(P <0. 05). The levels of serum S100B and Hcy in the observation group were significantly lower than those in the control group, and the ANG-1 level was significantly higher than that in the control group after treatment(P < 0. 05). The total effective rate in the observation group and the control group was 90. 48％(38 / 42)and 71. 43％(30 / 42)respectively,the total effective rate in the observation group was significantly higher than that in the control group(χ2 = 4. 659,P < 0. 05). The incidence of ad-verse reactions in the observation group and the control group was 11. 90％(5 / 42)and 9. 52％(4 / 42)respectively,there was no significant difference in the incidence of adverse reactions between the two groups(χ2 = 0. 092,P > 0. 05). Conclusion Butylphthalide can effectively regulate the levels of serum S100B,Hcy and ANG- 1,and improve the neurological function of patients with ACI.