Effects of InhaIational Anesthetics an Renal Function in Rabbits / 대한마취과학회지

ABSTRACT

In order to investigate the effects of inhalational anesthetics on renal function, small doses of ether or halothane were administered intravenously to rabbits without anesthesia, or disectly injected into the renal artery of the rabbits under urethane anesthesia. The following results were obtained. 1) 1mg/kg of 8% saturated solution of ether did not influence excretion of urine, creatinine and electrolytes, and osmolarity when intravenously administered over 10 minutes. 2) 1 mg/kg of the above solution markedly reduced urine volume, renal blood flow, glomerular filtration rate and excretion of electrolytes such as sodium, potassium,, chloride when directly injected into the renal artery over 10 minutes. 3) 0.5to 1.0% saturated solution of halothane did not influence renal functions when injected either intravenously or directly into the renal artery. 4) Reduced urine volume and sodium excretion were closely related to the decrease in renal blood flow when ether was injected directly into the renal artery. 5) From the above results it is suggested that halothane did not influence renal function while ether had a direct effect on renal function by hemodynamic change in renal circulation.