Ocular risk factors for polypoidal choroidal vasculopathy / 眼科新进展

ABSTRACT

Objective To evaluate potential risk factors for polypoidal choroidal vasculopathy (PCV) and PCV subtypes.Methods This was a retrospective case-control study.Totally 64 patients (64 eyes) of PCV (PCV group) in our hospital from July 2016 to January 2018 were enrolled and subgrouped into thick PCV and thin PCV.Additional 42 patients (42 eyes) who underwent cataract surgery in our hospital from January 2016 to December 2017 were collected as controls.Then the detailed history of all subjects were collected,including age,gender,best corrected visual acuity (BCVA),hypertension,dyslipidemia,cardiovascular diseases,ever-smoking history,alcohol consumption,and axial length.Univariate analysis and Logistic regression analysis was used to analyze the potential risk factors in patients from PCV group and PCV subgroups compared with controls.Results Univariate analysis showed that PCV had an older age (P =0.046),a higher incidence of hypertension (P =0.021),a greater proportion of smokers (P =0.036),and a shorter axial length (P =0.005) than controls,while there was no statistical difference in dyslipidemia,cardiovascular diseases and alcohol consumption between the two groups (all P ＞ 0.05).Logistic regression showed that age,hypertension,ever-smoking history,and axial length were still statistically significant (all P ＜ 0.05).In addition,comparison between thick PCV patients and controls revealed a statistically significant difference in hypertension,ever-smoking history,and axial length (all P ＜ 0.05),and there was a statistically significant difference between age,ever-smoking history and axial length between the thin PCV group and control group (all P ＜ 0.05).Thick PCV group and thin PCV group had statistically significant differences only in age and axial length (both P ＜ 0.05).Conclusion The potential risk factors for PCV includes age,hypertension,ever-smoking history,and axial length.In both PCV subtype groups,thick PCV patients are younger and have a shorter axial length than thin PCV patients,but systemic risk factors of thick PCV patients are similar to the thin PCV ones.