Comparison of different layers of subfoveal choroid in healthy pregnancy and pre-eclampsia / 眼科新进展

ABSTRACT

Objective To compare different layers of subfoveal choroidal thickness (SFCT) in normal subjects,healthy pregnant women and patients with pre-eclampsia (PE) using optical coherence tomography (OCT).Methods Twenty-two normal subjects,22 healthy pregnant women and 22 PE patients were included.All patients underwent the examinations including the best corrected visual acuity (BCVA),intraocular pressure,slit lamp,and OCT.The OCT examination was performed to measure SFCT,large choroidal vessel thickness (LCVT),and choroidal capillaries/medium choroidal vessel thickness (MCVT),and the differences between the three groups were compared.Results The differences in age and spherical equivalent among normal subjects,healthy pregnant women and patients with pre-eclampsia were not significant (all P ＞ 0.05).The differences in the gestational weeks between healthy pregnant women and PE patients was not significant (P ＞ 0.05).The mean SFCT of the normal group,healthy pregnant group and PE patient group was (263.45 ± 69.66) μm,(310.55 ±55.63) μm,and (350.41 ± 54.32) μm,accordingly,the mean LCVT of the normal group,healthy pregnant group and PE patient group was (188.25 ± 60.88) μm,(213.27 ±65.31) lμm,and (264.77 ± 56.21) μm,respectively;the mean MCVT of the normal group,healthy pregnant goup and PE patient group was (75.20 ± 33.65) μm,(97.27 ±22.14) μm,(85.64 ± 20.93) μm,respectively,with statistically significance in pairwise comparison (all P ＜ 0.05).The mean SFCT and MCVT of healthy pregnant women was significantly increased than that of the normal subjects (both P ＜ 0.05),but not for LCVT (P ＞ 0.05);whereas SFCT and LCVT of PE patients were significantly increased than those of healthy pregnant women (both P ＜ 0.05),but not for MCVT (P ＞ 0.05).Conclusion The SFCT and LCVT in PE patients are both higher than those in healthy pregnant women,and there is no significant difference in MCVT.