Probiotic based therapy for atopic dermatitis: Outcomes of clinical studies

ABSTRACT

Atopic dermatitis (AD) is one of the chronic inflammatory skin diseases characterized by conflicts in epidermal barrier and wired immune response. About 10％-20％ of the population is affected by AD, especially infants. Topical application of corticosteroids, antihistamines,and antibiotics are used to treat severe AD condition. Recent studies suggest that disturbance in skin and intestinal microbiota is majorly linked to skin diseases. Probiotics are known for the positive alteration of an individual's microbiome and associated with several health benefits. Clinical studies suggest that probiotic and synbiotic supplementation protect infants from a stringent AD to some extent. Reduction in the risk of AD development upon probiotic supplementation was not observed in all studied populations. Further studies are needed to regularize microbiome of skin and intestine in AD patients that may reduce AD severity.Present review summarizes the outcomes from clinical studies on AD using probiotic as an alternative treatment candidate.