Advances on the effect of post-translational modification on HMGB1 localization / 医学研究生学报

ABSTRACT

High mobility group box 1 (HMGB1) is a highly conserved and evolutionarily non-histone chromosomal protein that is modified by different PTMs,such as acetylation,glycosylation,phosphorylation,ADP-ribosylation,methylation and oxidation,which induces HMGB1 translocation to the cytosol or releases to the extracellular secretion following various stimuli,and its biological function also changes with the location change.This review aims to summarize the structure,the effect of PTMs on HMGB1 location and function.