Logistic Regression and ROC Curve for the Diagnostic Value of Progesterone, β-HCG and Serum Sugar Chain Protein 125 in Pregnancy Outcome in Patients with Early Threatened Abortion / 医学研究杂志

ABSTRACT

Objective To study the value of progesterone,β-HCG and serum streptavidin 125 (CA125) in predicting the outcome of pregnancy in patients with early threatened abortion by Logistic regression and ROC curve.Methods A total of 150 pregnant women who were pregnant with infertility from 5 to 7 weeks of gestation were enrolled in this study from August 2014 to October 2016.According to the outcome of pregnancy,the patients were divided into two groups:pregnancy group and spontaneous abortion group.Serum levels of progesterone,β-HCG and CA125 were detected in all patients with threatened abortion before treatment.The levels of progesterone,β-HCG and CA125 were detected in all the pregnant women with normal pregnancy in our hospital for the same period.All patients were followed up for 12 weeks.Logistic regression and ROC curve were used to analyze the value of progesterone,β-HCG and CA125 in the diagnosis of pregnant patients with threatened abortion.Results Seven cases of threatened abortion patients off.The levels of progesterone,β-HCG and CA125 in the normal pregnant group and the pregnant group were significantly higher than those in the abortion group (P ＜0.05).The area under the ROC curve of progesterone,β-HCG and CA125 in the early stage of pregnancy were 0.764,0.688 and 0.870 respectively.The area under the ROC curve of the early threatened abortion was 0.916.The specificity of progesterone,β-HCG,CA125 and the combined detection were 76.54％,61.05％,73.15％,89.09％,the specificity were 78.63％,72.38％,69.54％ and 93.25％ respectively,and the accuracy were 74.43％,70.15％,65.33％,89.77％.Conclusion The combination of progesterone,β-HCG and serum CA125 in the 5 ～ 7 weeks of pregnancy has a high clinical diagnostic value in prediction inevitable abortion.