Effect of Edaravone on Sympathetic Remodeling and Ventricular Arrhythmias in Rats Myocardial Infarction Model / 医药导报

ABSTRACT

Objective To investigate the effects of edaravone on sympathetic remodeling and ventricular arrhythmias in rats myocardial infarction model. Methods A total of 65 rats were randomly divided into the sham operation group (n=15), model control group(n=25),and edaravone group(n=25).Myocardial infarction model was established by ligation of the left ante-rior descending coronary artery.The edaravone group was injected intraperitoneally with edaravone (3 mg·kg-1·d-1), while the model control group and sham groups were injected with 0.9% sodium chloride soution.7 days after operation,the hemodynamics were detected and then ventricular arrhythmia at the peri-infarct zones was induced.After these studies,the expression of the signa-ling pathway NF-κB/p65, IκBα, p-IкBα at the peri-infarct zones were examined by western blotting, while the expression of GAP43 and TH were examined by immunohistochemical method. Results Compared with the sham group,the inducibility of ven-tricular arrhythmia after MI was increased,the expression of GAP43 and TH were increased significantly(P<0.05),the signaling pathway of NF-κB was activated,while compared with the model control group,all of the above were suppressed by edaravone(P<0.05). Conclusion Edaravone inhibits sympathetic remodeling and ventricular arrhythmias after myocardial infarction, the effects of which may be partly related to the inhibition of NF-κB pathway,(P<0.05).