Oxytocin and Oxytocin Antagonist Metabolism in the Plasma of Pregnant Women / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 921-925, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-70108
ABSTRACT
OBJECTIVE:
Oxytocin antagonists maybe useful in inhibiting the uterine contractions of preterm labor. One such compound is TT-235. The purpose of this study was to compare the resistance of TT-235 and oxytocin to enzymatic degradation by oxytocinase in pregnant human.METHODS:
Blood samples from pregnant women not in labor were incubated in vitro with known amounts of oxytocin and TT-235. Samples were collected at 0, 15, 30, 45 and 60 minute intervals for oxytocin analysis and at 0, 10, 60 and 360 minutes for TT-235 analysis. Oxytocin was analyzed by radioimmunoassay after extraction while TT-235 was analyzed by radioreceptor assay.RESULTS:
In human blood, oxytocin was readily metabolized with greater than 83% disappearance over the 60 minute incubation period. In contrast, TT-235 was stable up to 360 minutes of incubation.CONCLUSION:
This study suggests that (1) blood from pregnant human does contain oxytocinase at least in vitro; and (2) TT-235 was resistant to enzymatic degradation by human blood, implying that this oxytocin antagonist may have prolonged activity in vivo in humans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cistinil Aminopeptidasa
/
Plasma
/
Ensayo de Unión Radioligante
/
Contracción Uterina
/
Útero
/
Oxitocina
/
Radioinmunoensayo
/
Mujeres Embarazadas
/
Trabajo de Parto Prematuro
/
Metabolismo
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2002
Tipo del documento:
Artículo
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