Survey for four consecutive years uric acid levels and related factors in a company in the Ordos region population / 中国基层医药

ABSTRACT

Objective To analyze the trend and influencing factors of serum uric acid level in a fixed population in Erdos area,to provide a basis for clinical diagnosis and treatment.Methods Chose a fixed population of a company in Ordos region,the cluster sampling method was used to investigate a total of 2911 people of the company from 2013 to 2016.The levels of uric acid were analyzed for 4 consecutive years and compared with the results of the early years of the region,and the factors influencing uric acid were analyzed.Results One-way ANOVA statistical analysis showed that within four years the period between the male respondents in different yearsF(1.254,5.018) =6.612,P =0.046;between different age groupsF (4.000,12.000) =25.920,P ＜ 0.000;female between different yearsF(1.768,7.073) =257.300,P ＜ 0.000;between different age groups F(4.000,12.000) =202.200,P ＜ 0.000.Compared with the early results,male respondents between 2009,2011,2016 comparisonF(1.069,4.277) =101.700,P =0.000;between different age groupsF (4.000,8.000) =11.650,P =0.002;female respondents between 2009,2011,2016 comparisonF (1.851,7.403) =141.800,P ＜ 0.000;between different age groups F(4.000,8.000) =13.480,P =0.001,there were significant differences.The Cox-Staut trend test was used to analyze the prevalence of the respondents in 2013-2016,male crude prevalence rates were 20.32％,25.29％,27.32％,28.46％,respectively,x2 =12.768,P ＜0.05;male standardized prevalence rates were 19.73％,23.66％,25.67％,26.52％,respectively,x2 =13.441,P ＜ 0.05;female crude prevalence rates were 5.59％,6.88％,7.62％,7.98％,respectively,x2 =18.435,P ＜ 0.05;female standardized prevalence rates were 5.32％,5.97％,7.01％,7.11％,respectively,x2 =19.325,P ＜ 0.05.The subjects were divided into blood uric acid levels,an independent sample t test was performed on 17 items,BMI,education level,diet,smoking,drinking,GLU,TC,LDL-C had statistically significant differences (all P ＜ 0.05).Non-conditional logistic regression analysis was performed on the relevant factors of hyperuricemia (H UA),sex (OR =17.129,95 ％ CI2.795 ～ 104.970,P ＜ 0.01),BMI (OR =17.129,95％ CI2.795 ～ 104.970,P ＜ 0.01),drinking (OR =9.467,95 ％ CI2.235 ～ 40.094,P ＜ 0.01),smoking (OR =6.581,95％ CI1.674 ～ 25.865,P ＜ 0.01),LDL (OR =14.978,95％ CI1.826 ～ 122.863,P ＜ 0.05),HBA1C(OR=21.403,95％CI1.417 ～323.395,P＜0.05) were high risk factors for HUA.Conclusion In recent years,the blood uric acid level has increased significantly,many factors affect blood uric acid should be strengthened emphasis on health education and treatment of HUA.