Clinical significance of IL-2 and IL-6 detection in the diagnosis and treatment of patients with condyloma acuminatum / 中国基层医药

ABSTRACT

Objective To investigate the clinical significance of IL -2 and IL-6 detection in the diagnosis and treatment of patients with condyloma acuminatum .Methods 45 patients with condyloma acuminatum were selected,and 45 healthy people were selected as control .Enzyme linked immunosorbent assay (ELISA) and transcrip-tion polymerase chain reaction ( RT-PCR) were used to detect the levels of IL -2 and IL-6 in patients before and after treatment,and the levels of IL-2 and IL-6 were detected in healthy controls .Results Before treatment,the serum contents of IL-2 and IL-6 in patients with condyloma acuminatum ,after treatment were (3.28 ±0.97)μg/L, (4.98 ±1.83)pg/L,respectively,the serum IL-2,IL-6 contents were (6.01 ±0.42)μg/L,(7.05 ±1.94)pg/L, respectively.The serum IL-2 and IL-6 levels of control group were (8.09 ±1.36)μg/L,(9.12 ±2.51) pg/L, respectively,the differences between the two groups were statistically significant (t=5.82,5.46,P<0.05,0.01). Before treatment ,the IL-2 and IL-6 mRNA expression in skin tissue of patients with condyloma acuminatum after treatment were (0.327 ±0.048),(0.457 ±0.093),which were (0.512 ±0.021),(0.641 ±0.154),respectively. The IL-2 and IL -6 mRNA expression in skin tissue of the control group were (0.859 ±0.125),(0.932 ± 0.063),the differences between the two groups were statistically significant ( t =4.68,6.74;P <0.05,0.01). Conclusion There are serious defects in the cellular immune function of patients with condyloma acuminatum .The detection of IL-2 and IL-6 levels in patients with condyloma acuminatum has important clinical value for the occur -rence,treatment and prognosis of the disease .