Effect of octreotide combined with lactulose enema therapy in the treatment of acute pancreatitis / 中国基层医药

ABSTRACT

Objective To study the effect of octreotide combined with lactulose enema therapy in the treatment of acute pancreatitis .Methods 80 cases with acute pancreatitis were selected as the research subjects , they were randomly divided into two groups , 40 cases in each group .The control group was treated with octreotide , and the observation group was given octreotide combined with lactulose enema treatment .The clinical total effective rate ,symp-toms time,hospitalization time and inflammatory cytokines were compared in the groups .Results The total effective rate of the observation group was significantly higher than that of the control group (95.00％ vs.80.00％,χ2 =4.114,P<0.05).The remission time of abdominal discomfort ,intestinal function recovery time ,serum amylase recov-ery time and hospitalization time in the observation group were (2.19 ±0.82)d,(2.96 ±1.15)d,(4.67 ±1.43)d, (10.37 ±2.14) d,respectivel,which were significantly shorter than those in the control group ( t=8.266,5.516, 8.084,8.376,all P<0.05).After treatment,the levels of TNF -alpha,IL-6,hs-CRP in the observation group were (36.78 ±14.67)ng/L,(109.53 ±36.29)pg/mL,(10.32 ±3.89)mg/L,respectivel,which were significantly lower than those in the control group (t=4.424,4.386,4.622,all P<0.05).Conclusion The curative effect of octreotide and lactulose enema in the treatment of acute pancreatitis is significant , it can effectively improve the patients'clinical symptoms ,also can inhibit the inflammatory cytokines and improve the prognosis .