Efficacy of carbamazepine combined with ENP in the treatment of epilepsy patients and its influence on intel- ligence and electroencephalogram / 中国基层医药

ABSTRACT

Objective To study the effect of carbamazepine and ENP in the treatment of epilepsy and its influence on intelligence and electroencephalogram .Methods Eighty-six patients with epilepsy were enrolled . According to the random number method,they were divided into observation group and the control group ,43 cases in each groups.The observation group was given carbamazepine combination with ENP ,while the control group was given carbamazepine.The duration of epileptic seizure and the number of seizures ,intelligence,P300 wave amplitude and wave latency,and adverse effects were compared between the two groups .Results The total effective rate in the observation group was significantly higher than that in the control group [93.02%(40/43) vs.74.42%(32 /43)] (χ2 =5.460,P <0.05).The duration of seizure of the observation group was shorter than that of the control group [(2.31 ±0.26)times /min vs.(3.16 ±0.38)times /min](t =12.106,P <0.05),and the frequency of seizures of the observation group was shorter than that of the control group [(0.82 ±0.11)time/year vs.(1.34 ±0.15)time/year](t =18.332,P <0.05).The ability of self-discernment,analogical comparison,comparative reasoning,series relation and abstract reasoning ability of the observation group were significantly higher than those of the control group (t =7.557,13.075,2.082,7.615,9.903,all P <0.05).The improvement of SPM level in the observation group was better than that in the control group (t =4.705,P <0.05).The amplitude of P300 wave of the observation group was significantly higher than that of the control group [(6.87 ±0.68)μV vs.(5.24 ±0.51)μV](t =12.575,P <0.05). The latency of P300 wave of the observation group was significantly lower than that of the control group [(305.32 ± 17.34)ms vs.(326.45 ±19.15)ms](t =5.363,P <0.05).There was no statistically significant difference in the incidence rate of adverse reaction between the observation group and the control group (P >0.05).Conclusion The combination of carbamazepine and ENP in the treatment of epilepsy can reduce the duration and frequency of seizures,and improve the intelligence level and electroencephalogram .The clinical efficacy is good and the safety is high .