Pioglitazone treatment decreases follicular fluid levels of tumor necrosis factor-alpha and interleukin-6 in patients with polycystic ovary syndrome / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 98-102, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-70202
ABSTRACT
OBJECTIVE:
To investigate the effects of pioglitazone on controlled ovarian stimulation (COS), IVF outcomes, and follicular fluid (FF) cytokine concentrations in patients with polycystic ovary syndrome (PCOS).METHODS:
Eighty-six infertile patients with PCOS resistant to clomiphene citrate were randomized to receive pioglitazone (30 mg/day) or placebo on the starting day of oral contraceptive (OC) pretreatment, followed by an IVF protocol using a GnRH antagonist. Pioglitazone or placebo was administered once daily from the starting day of OC to the day of hCG injection.RESULTS:
Total dose and days of recombinant follicle-stimulating hormone administered, and the numbers of retrieved and mature oocytes, were significantly lower in the pioglitazone group than in the control group. FF tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) concentrations at oocyte retrieval were also significantly lower in the pioglitazone group. The clinical pregnancy rate was higher and the incidence of severe ovarian hyperstimulation syndrome was lower in the pioglitazone group, but the differences were not statistically significant.CONCLUSION:
Pioglitazone reduces FF TNF-alpha and IL-6 levels, and may improve ovarian response to COS in patients with PCOS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oocitos
/
Inducción de la Ovulación
/
Síndrome del Ovario Poliquístico
/
Fertilización In Vitro
/
Líquido Folicular
/
Incidencia
/
Hormona Liberadora de Gonadotropina
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Síndrome de Hiperestimulación Ovárica
Tipo de estudio:
Ensayo Clínico Controlado
/
Guía de Práctica Clínica
/
Estudio de incidencia
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Clinical and Experimental Reproductive Medicine
Año:
2011
Tipo del documento:
Artículo
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