Analysis of the clinical effect of Kangfuxin Liquid in the treatment of chronic gingivitis in orthodontic patients / 中国基层医药

ABSTRACT

Objective To study the clinical effect of Kangfuxin Liquid in the treatment of orthodontic children with chronic gingivitis.Methods From January 2014 to February 2016,a total of 100 orthodontic children with chronic gingivitis in Zhejiang Greentown Cardiovascular Hospital were selected in the research.The patients were randomly divided into the control group and observation group according to the computer numeral list method,with 50 cases in each group.The control group was treated with oral scaling,children in the observation group were treated with Kangfuxin Liquid on the basis of oral scaling.The clinical curative effect,plaque index,sulcus bleeding index,pain score,swelling score,the levels of inflammatory cytokines in gingival crevicular fluid were compared between the two groups.Results The total effective rate of the observation group was 96％,which was higher than 82％of the control group(χ2 =5.005,P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling scores in the two groups were significantly lower than those before treatment(all P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling score in the observation group were(1.14 ± 0.36)points,(1.96 ±0.64)points,(2.94 ±0.96)points,(3.32 ±0.97)points,respectively,which were significantly lower than those in the control group(t=4.862,5.041,5.513,5.041,all P<0.05).After treatment,the interleukin 1 beta(IL-1 beta),prostaglandin E2(PGE2),soluble adhesion molecule 1(sICAM-1)of gingival sulcus fluid in the two groups were significantly lower than those before treatment(all P<0.05),while after treatment,the levels of IL-1 beta,PGE2 sICAM-1 in the observation group were(10.32 ±1.19)ng/L,(246.53 ±36.29)ng/L,(135.23 ± 14.32)μg/L,respectively,which were lower than those in the control group(t=4.973,5.211,4.973,all P<0.05).Conclusion The use of Kangfuxin Liquid on chronic gingivitis after orthodontic treatment has significant clinical efficacy,can effectively reduce periodontal inflammation in patients with gingival swelling and pain,and can effectively inhibit inflammatory cytokines in gingival crevicular fluid,and improve the prognosis.