Progress in the pathogenesis of hepatic fibrosis / 中国基层医药

ABSTRACT

Hepatic fibrosis is an important part of development of chronic liver inflammation further to cirrhosis,liver cancer.The formation of hepatic fibrosis is a complex pathological process involving multiple cells and multiple factors.The progress of hepatic stellate cells(HSC),extracellular matrix(ECM),cytokines and autophagy,sphingosine kinase 1(Spk1)in the pathogenesis of hepatic fibrosis is reviewed in this study.