Effect of inflammasome activation on local immune microenvironment of injured spinal cords / 中国免疫学杂志

ABSTRACT

The inflammasome is a kind of multi-protein complexes with high molecular weight that can induce cells to die under the pathological conditions of inflammation and stress.After spinal cord injury,there are a variety of immune cells with different functions in the local injured microenvironment.Under natural conditions,the immune cell subsets in the local injured microenvironment are imbalance in"yin and yang",and the destructive subpopulations and cytokines are dominant.This is an important mechanism of pathological damage caused by SCI.Inflammasome plays an extremely important role in the process of central nervous system injury.Although activation of inflammasome and IL-1β and IL-18 are all expressed at the site of injured spinal cords,their effects on local immune microenvironment of SCI have not yet been reported.According to the current research progress,we believe that activation of inflammasome can affect the local immune microenvironment of SCI.This is an interesting topic,but few related studies have been re-ported.This review focuses on four types of inflammasomes associated with CNS injury.Their structure,function and so on will be ex-pounded.The relationship between inflammasome activation and immune microenvironment of SCI will also be discussed.