Research progress of cGAS-STING signaling pathway in anti-DNA virus immunity / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 103-107, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-703306
ABSTRACT
Innate immune system rapidly detects and responds to viruses at the early stage of viral infection. However,the mechanisms by which the immune system recognizes and eliminates them have not been fully clarified so far. Studies have shown that receptors are the primary tool for cell recognition and detection of viruses, and cyclic GMP-AMP synthase(cGAS)is one of the newly found DNA recognition receptors. cGAS transmits the signal to the downstream protein called STING(stimulator of interferon genes)and mediates the production of type I interferon(IFN-I),thereby to initiates the antiviral immunity of cells. This review briefly introduces the mechanism of the cGAS-STING signaling pathway, in order to provide a theoretical basis for the research and development of new antiviral drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Comparative Medicine
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS