Pathogenetic and therapeutic roles of non-coding RNAs on major depressive disorder / 中华行为医学与脑科学杂志

ABSTRACT

The major depressive disorder (MDD) affecting a large amount of population still has unknown neurobiological mechanisms and dissatisfactory treatment response.Given the urgently need for effective predictive markers for diagnosis and treatment,epigenetic studies of neuropsychiatric disorders including non-coding RNAs (ncRNAs) expand the research.Non-coding RNAs including microRNA,long noncoding RNA and circular RNA,may play important roles on neural differentiation,synaptic plasticity and central neurological reaction of stress during the course of antidepressasnt treatment.The current knowledge was summarized about posttranscriptional regulation of ncRNAs in major depression and discussed the potential biomarker value of ncRNAs for treatment evaluation in the context of individualized treatment.