Advances of event-related potentials in the early recognition of childhood schizophrenia / 中华行为医学与脑科学杂志

ABSTRACT

Schizophrenia is a common severe mental illness with unknown etiology, 1/7-1/3 of which onset in children and adolescents. The treatment of childhood schizophrenia is more difficult,and the prognosis is even worse,so the early identification and timely intervention has great significance. Event-relat-ed potentials ( ERPs) are bioelectrical activities that occur in the brain during external or internal stimuli. They reflect the electrophysiological changes in the brain during cognitive activity. In recent years,scholars at home and abroad have tried to find biomarkers of early identification of childhood schizophrenia through ERPs. The main contents includeerror related negativity (ERN),mismatched negativity (MMN),N100, P300 and so on.It was found that children and adolescents with schizophrenia prodromal symptoms and high-risk children and adolescents have decreased ERN,MMN,N100,P300 amplitudes,and prolonged P300 laten-cy. However,some of these results are still lack of consistency and need further research. And combined with brain imaging and molecular biology for clinical validation,it will be more helpful to the early identification of childhood schizophrenia.