Insight into the Pathogenesis of Lyme Disease
Journal of Bacteriology and Virology
;
: 10-22, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-70414
ABSTRACT
Lyme disease is the most common vector-borne disease in the United States and Europe, caused by a tick-borne spirochete, Borrelia burgdorferi. Life cycle alternation between arthropod and mammals enhanced B. burgdorferi to adapt to two diverse niches. Although B. burgdorferi infection in these reservoir hosts appears asymptomatic, infection in human can typically cause inflammation in the skin, nervous system, musculoskeletal system and heart. In this review, we discuss the basic molecular characteristics and cell biology of B. burgdorferi and provide an overview of spirochete-induced activation of innate and adaptive immunity, resulting in particular immunopathology. Advancing understanding of the immune evasion mechanisms of B. burgdorferi provides important implications for ongoing research and clinical practice of Lyme disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artrópodos
/
Piel
/
Spirochaetales
/
Estados Unidos
/
Enfermedad de Lyme
/
Borrelia burgdorferi
/
Europa (Continente)
/
Evasión Inmune
/
Inmunidad Adaptativa
/
Corazón
Tipo de estudio:
Estudio de etiología
Límite:
Humanos
País/Región como asunto:
America del Norte
/
Europa
Idioma:
Inglés
Revista:
Journal of Bacteriology and Virology
Año:
2014
Tipo del documento:
Artículo
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